Signal detection on a patient cohort: A disproportionality analysis of the ANRS CO22 HEPATHER cohort to identify associations between direct acting antivirals and adverse events in patients with hepatitis C virus chronic infection.
Sarah F FeldmanNathanaël LapidusCéline DorivalAlpha DialloImane AmriHélène FontaineStanislas PolFabrice Carratnull nullPublished in: Pharmacoepidemiology and drug safety (2018)
The disproportionality method can help with early detection of potential ADRs in patient cohorts. Detected associations need to be confirmed by a review of clinical data.