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Novel Molecular Mechanism of Aspirin and Celecoxib Targeting Mammalian Neuraminidase-1 Impedes Epidermal Growth Factor Receptor Signaling Axis and Induces Apoptosis in Pancreatic Cancer Cells.

Bessi QorriWilliam HarlessMyron R Szewczuk
Published in: Drug design, development and therapy (2020)
These findings may be the missing link connecting the anti-cancer efficacy of NSAIDs to the role of glycosylation in inflammation and tumorigenesis.
Keyphrases
  • growth factor
  • anti inflammatory drugs
  • low dose
  • oxidative stress
  • cancer therapy
  • cardiovascular events
  • antiplatelet therapy
  • wound healing
  • cardiovascular disease
  • acute coronary syndrome
  • drug delivery