Rapid and accurate method for quantifying busulfan in plasma samples by isocratic liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Yolanda Villena-OrtizLaura Castellote-BellésLuisa Martinez-SanchezMaría I Benítez-CarabanteMarta MiaronsJaume Vima-BofarullRaquel Barquin-DelPinoRosanna PaciucciFrancisco Rodríguez-FríasRoser Ferrer-CostaErnesto CasisJoan López-Hellín

Published in: Advances in laboratory medicine (2022)

This method was successfully validated and was found to be robust enough for therapeutic drug monitoring in a clinical setting.

Keyphrases

liquid chromatography tandem mass spectrometry
simultaneous determination
ms ms
solid phase extraction
acute lymphoblastic leukemia
mass spectrometry
loop mediated isothermal amplification
liquid chromatography