Evaluation of the behavioral, histopathological, and immunohistochemical effects resulting from ventriculosubcutaneous shunt obstruction in kaolin-induced hydrocephalus in rats.
Stephanie Naomi Funo de SouzaHelio Rubens MachadoLuisa da Silva LopesPamella da Silva Beggiora MarquesStephanya Covas da SilvaMaurício DutraDavi Casale AragonMarcelo Volpon SantosPublished in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2024)
Obstruction of the shunt results in impaired performance of behavioral tests and causes irreversible histopathological changes when compared to findings in the group with treated hydrocephalus, even after unblocking the system. The developed model is feasible and efficient in simulating the clinical context of shunt dysfunction.