Metastatic breast cancer cells induce altered microglial morphology and electrical excitability in vivo.

Anna SimonMing YangJoanne L MarrisonAndrew D JamesMark J HuntPeter J O'ToolePaul M KayeMiles A WhittingtonSangeeta ChawlaWilliam John Brackenbury

Published in: Journal of neuroinflammation (2020)

These data suggest that peritumoral microglial activation and accumulation may play a critical role in local tissue changes underpinning aberrant cortical activity, which offers a possible mechanism for the disrupted cognitive performance and seizures seen in patients with metastatic breast cancer.

Keyphrases

metastatic breast cancer
inflammatory response
induced apoptosis
lipopolysaccharide induced
lps induced
neuropathic pain
cell cycle arrest
electronic health record
endoplasmic reticulum stress
signaling pathway
big data
spinal cord
cell proliferation
pi k akt
working memory
data analysis