Computational simulation of JAK/STAT signaling in somatic versus germline stem cells.

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2023)

The simulation suggests that the duration of ligand exposure could explain the observed opposite effects of JAK/STAT activation on heterochromatin in somatic versus GSCs.

Keyphrases

stem cells
copy number
dna methylation
bone marrow
genome wide