Drug exposure of first-line anti-tuberculosis drugs in China: A prospective pharmacological cohort study.

Yazhou GaoLina Davies ForsmanWeihua RenXubin ZhengZiwei BaoYi HuJudith BruchfeldJan-Willem Alffenaar

Published in: British journal of clinical pharmacology (2020)

PK variability of first-line anti-TB drugs is common in Chinese TB patients. The developed population PK models can be used to optimize drug exposures in Chinese patients. Moreover, standard dosing needs to be adjusted to increase target attainment.

Keyphrases

mycobacterium tuberculosis
end stage renal disease
chronic kidney disease
ejection fraction
newly diagnosed
drug induced
prognostic factors
peritoneal dialysis
air pollution