The role of AMPK in pancreatic cancer: from carcinogenesis to treatment.
Shahrzad Shahrokhi NejadSepideh RaziNima RezaeiPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2024)
Pancreatic cancer has doubled over the previous two decades. Routine therapies are becoming incredibly resistant and failing to compensate for the burden caused by this aggressive neoplasm. As genetic susceptibility has always been a highlighted concern for this disease, identifying the molecular pathways involved in the survival and function of pancreatic cancer cells provides insight into its variant etiologies, one of which is the role of AMPK. This regulating factor of cell metabolism is crucial in the homeostasis and growth of the cell. Herein, we review the possible role of AMPK in pancreatic cancer while considering its leading effects on glycolysis and autophagy. Then, we assess the probable therapeutic agents that have resulted from the suggested pathways. Studying the underlying genetic changes in pancreatic cancer provides a chance to detect and treat patients suffering from advanced stages of the disease, and those who have given up their hope on conventional therapies can gain an opportunity to combat this cancer.
Keyphrases
- skeletal muscle
- end stage renal disease
- single cell
- cell therapy
- ejection fraction
- genome wide
- newly diagnosed
- chronic kidney disease
- cell death
- protein kinase
- peritoneal dialysis
- copy number
- oxidative stress
- papillary thyroid
- signaling pathway
- stem cells
- squamous cell carcinoma
- mesenchymal stem cells
- single molecule
- squamous cell
- free survival