Genetic and environmental influences on longitudinal frailty trajectories from adulthood into old age.

Jonathan K L Mak Ralf Kuja-Halkola Ge BaiLinda B HassingNancy L PedersenSara Hägg Juulia JylhäväChandra A Reynolds

Published in: The journals of gerontology. Series A, Biological sciences and medical sciences (2022)

Increased heterogeneity of frailty in late life is mainly attributable to environmental influences, highlighting the importance of targeting environmental risk factors to mitigate frailty in older adults.

Keyphrases

risk factors
human health
community dwelling
depressive symptoms
life cycle
physical activity
risk assessment
genome wide
single cell
cancer therapy
gene expression
copy number
dna methylation
early life