Genetic characteristics involving the PD-1/PD-L1/L2 and CD73/A2aR axes and the immunosuppressive microenvironment in DLBCL.

Tingting ZhangHengqi LiuLei JiaoZhenzhen ZhangJin HeLanfang LiLihua QiuZhengzi QianShiyong ZhouWenchen GongBin MengXiubao RenHuilai ZhangXianhuo Wang

Published in: Journal for immunotherapy of cancer (2022)

This study describes the additional genetic basis of PD-L1 overexpression and characterizes certain genetic alterations of CD73/A2aR in DLBCL. The degree of T-cell dysfunction is correlated with clinical outcomes. Strategies that reverse T-cell dysfunction by inhibiting PD-1/PD-L1/L2, particularly in combination with CD73/A2aR, may show potential as effective therapeutic options for DLBCL.

Keyphrases

diffuse large b cell lymphoma
genome wide
copy number
nk cells
oxidative stress
stem cells
signaling pathway
transcription factor
gene expression
climate change