Transmembrane protease serine 5: a novel Schwann cell plasma marker for CMT1A.
Hongge WangMatthew DavisonKathryn WangTai-He XiaMartin KramerKatherine CallJun LuoXingyao WuRiccardo ZuccarinoChelsea BaconYunhong BaiJohn J MoranLaurie GutmannShawna M E FeelyTiffany GriderAlexander M RossorMary M ReillyJohn SvarenMichael E ShyPublished in: Annals of clinical and translational neurology (2019)
These data identify the first Schwann cell-specific protein that is elevated in plasma of CMT1A patients, and may provide a disease marker and a potentially treatment-responsive biomarker with good disease specificity for clinical trials.
Keyphrases
- clinical trial
- end stage renal disease
- single cell
- cell therapy
- newly diagnosed
- chronic kidney disease
- ejection fraction
- peripheral nerve
- peritoneal dialysis
- prognostic factors
- cancer therapy
- machine learning
- bone marrow
- patient reported outcomes
- binding protein
- protein kinase
- amino acid
- combination therapy
- patient reported