Hydrido-Cobalt Complexes for the Chemo- and Regioselective 1,2-Silylative Dearomatization of N -Heteroarenes.
Cassandre C BoriesGeoffrey GontardMarion BarbazangesEtienne DeratMarc PetitPublished in: Organic letters (2023)
We describe an efficient regio- and chemoselective dearomatization of N -heteroarenes using hydrido-cobalt catalysts. Reactions were performed under mild conditions on a wide range of N -heteroarenes leading exclusively to the silyl-1,2-dihydroheteroarene. Various quinolines and pyridines bearing electron-donating and electron-withdrawing substituents are compatible with this methodology. DFT calculations, NMR spectroscopic studies, and X-ray diffraction analysis underlined the importance of a second silane for the final step of the reaction.
Keyphrases
- electron microscopy
- density functional theory
- molecular docking
- high resolution
- metal organic framework
- reduced graphene oxide
- electron transfer
- magnetic resonance
- molecular dynamics
- photodynamic therapy
- highly efficient
- carbon nanotubes
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- crystal structure
- computed tomography
- magnetic resonance imaging
- dual energy
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- mass spectrometry
- solid state