Effects of long-term fluoride exposure are associated with oxidative biochemistry impairment and global proteomic modulation, but not genotoxicity, in parotid glands of mice.
Giza Hellen Nonato MirandaLeidiane Alencar de Oliveira LimaLeonardo Oliveira BittencourtSávio Monteiro Dos SantosMichel Platini Caldas de SouzaLygia Sega NogueiraEdivaldo Herculano Corrêa de OliveiraMarta Chagas MonteiroAline DionizioAline Lima LeiteJuliano Pelim PessanMarília Afonso Rabelo BuzalafRafael Rodrigues LimaPublished in: PloS one (2022)
Thus, our results suggest that long-term exposure to fluoride promoted modulation of the proteomic and biochemical profile in the parotid glands, without inducing damage to the genetic component. These findings reinforce the importance of rationalizing the use of fluorides to maximize their preventative effects while minimizing the environmental risks.