Characterization of the binding of tau imaging ligands to melanin-containing cells: putative off-target-binding site.

Tetsuro TagoJun ToyoharaRyuichi HaradaShozo FurumotoNubuyuki OkamuraYukitsuka KudoJunko Takahashi-FujigasakiShigeo MurayamaKenji Ishii

Published in: Annals of nuclear medicine (2019)

These studies suggest that the binding properties of [18F]AV-1451 and [18F]THK5351 are sufficient to expect highlighting of tissues with a high density of MCCs. The findings of the present study should aid the development of neuroimaging ligands that do not bind to MCC.

Keyphrases

high density
induced apoptosis
high resolution
cell cycle arrest
gene expression
dna binding
oxidative stress
cerebrospinal fluid
cell death