A Profile of Avelumab Plus Axitinib in the Treatment of Renal Cell Carcinoma.
Manuela Tiako MeyoJeanne ChenFrancois GoldwasserLaure HirschOlivier HuillardPublished in: Therapeutics and clinical risk management (2022)
Until recently, the approved first-line treatment for metastatic RCC (mRCC) consisted of tyrosine kinase inhibitors (TKI) targeting the vascular endothelial growth factor receptors (VEGFR) monotherapy. The landscape of first-line treatment has been transformed in the last few years with the advent of immune checkpoint inhibitors (ICI) or VEGFR TKI plus ICI combinations. This article focuses on the profile of one of these ICI plus VEGFR TKI combination, avelumab plus axitinib. We detail the characteristics of each drug separately, and then we explore the rationale for their association, its efficacy and the resulting toxicity. Finally, we examine the factors associated with avelumab plus axitinib outcomes, and their impact on therapeutic strategy.
Keyphrases
- vascular endothelial growth factor
- renal cell carcinoma
- chronic myeloid leukemia
- tyrosine kinase
- metastatic renal cell carcinoma
- advanced non small cell lung cancer
- endothelial cells
- combination therapy
- squamous cell carcinoma
- epidermal growth factor receptor
- oxidative stress
- clinical trial
- emergency department
- cancer therapy
- metabolic syndrome
- single cell
- skeletal muscle
- oxide nanoparticles
- drug administration