Detection of minority drug resistant mutations in Malawian HIV-1 subtype C-positive patients initiating and on first-line antiretroviral therapy.
Zhiyong ZhouKevin TangGuoqing ZhangNellie Wadonda-KabondoKundai MoyoLori A RoweJoshua R DeVosNick WagarDu-Ping ZhengHongxiong GuoJohn NkengasongMike FraceScott SammonsChunfu YangPublished in: African journal of laboratory medicine (2018)
The results revealed the presence of minority DRMs to NRTIs and NNRTIs in specimens collected at baseline and virologic failure time points. These minority DRMs not only increased resistance levels to NRTIs and NNRTIs for the prescribed ART, but also expanded resistance to additional major first-line ART drugs. This study suggested that drug resistance testing that uses more sensitive technologies, is needed in this setting.
Keyphrases
- antiretroviral therapy
- hiv infected
- drug resistant
- hiv positive
- human immunodeficiency virus
- hiv infected patients
- hiv aids
- multidrug resistant
- end stage renal disease
- acinetobacter baumannii
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- single cell
- hepatitis c virus
- loop mediated isothermal amplification
- patient reported
- sensitive detection
- south africa