Hyperglycaemia aggravates periodontal inflamm-aging by promoting SETDB1-mediated LINE-1 de-repression in macrophages.

Ziqi YueLuningxiao NieNing JiYuezhang SunKangjian ZhuHaonan ZouXiuxiu SongJiao ChenQi Wang

Published in: Journal of clinical periodontology (2023)

The findings of this study show that SETDB1 regulates senescence-like phenotypical switching of macrophages and is a potential candidate for the treatment of diabetes-induced periodontal inflamm-aging.

Keyphrases

type diabetes
cardiovascular disease
dna damage
glycemic control
stress induced
adipose tissue
drug induced
risk assessment
oxidative stress
skeletal muscle
combination therapy
weight loss