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Comparison of Proteomic Measurements Across Platforms in the Atherosclerosis Risk in Communities (ARIC) Study.

Mary R RooneyJingsha ChenChristie M BallantyneRon C HoogeveenOlive TangMorgan E GramsAdrienne TinChiadi E NdumeleFaiez ZannadDavid J CouperWeihong TangElizabeth SelvinJosef Coresh
Published in: Clinical chemistry (2022)
There is variation in the quantitative measurements for many proteins across aptamer-based and proximity-extension immunoassays (approximately 1/2 showing good or modest correlation and approximately 1/2 poor correlation) and also for correlations of these highly multiplexed technologies with targeted immunoassays. Design and interpretation of protein quantification studies should be informed by the variation across measurement techniques for each protein.
Keyphrases
  • protein protein
  • cardiovascular disease
  • amino acid
  • gold nanoparticles
  • high resolution
  • binding protein
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  • cancer therapy
  • sensitive detection
  • type diabetes
  • drug delivery
  • mass spectrometry