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Anti-inflammatory phomalichenones from an endolichenic fungus Phoma sp.

Jong Won KimWonmin KoEun KimGil Soo KimGwi Ja HwangSangkeun SonMin-Hye JeongJae-Seoun HurHyuncheol OhSung-Kyun KoJae-Hyuk JangJong Seog Ahn
Published in: The Journal of antibiotics (2018)
Four new compounds, phomalichenones A-D (1-4), and seven known compounds (5-11) were isolated from the cultures of an endolichenic fungus Phoma sp. EL002650. Their structures were determined by the analysis of their spectroscopic data (NMR and MS). Compounds 1 and 6 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. In addition, compound 1 diminished the protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and decreased the mRNA expression levels of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin(IL)-1β, and IL-6.
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