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Novel vic-dioximes: synthesis, structure characterization, and antimicrobial activity evaluation.

Dumitru UrecheIon BulhacAlexandru CiocarlanDaniel RoshcaLucian LupascuPaulina Bourosh
Published in: Turkish journal of chemistry (2021)
The vic-dioximes are compounds with various industrial uses and scientific applications. Many coordination compounds have been synthesized based on vic-dioximes. This study presents the synthesis and full characterization of two vic-dioximes based on dichloroglyoxime, p -aminobenzoic acid, and p -aminotoluene. Their structures were proved by IR, 1 H, 13 C and 15 N NMR spectral analysis, and single crystal X-ray diffraction. One of the reported vic-dioximes, bis (di- p -aminotoluene)glyoxime mono- p -aminotoluene trihydrate showed good to moderate antimicrobial activity against both nonpathogenic gram-positive and gram-negative bacteria ( Bacillus subtilis and Pseudomonas fluorescens ), phytopathogenic ( Xanthomonas campestris , Erwinia amylovora , E. carotovora ) and the fungi ( Candida utilis and Saccharomyces cerevisiae ) at MIC - 70-150 μg/mL.
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