Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway.

Trayambak PathakJ Cory BensonMartin T JohnsonPing XinAhmed Emam AbdelnabyVonn WalterWalter A KoltunGregory S YochumNadine Hempel Mohamed Trebak

Published in: bioRxiv : the preprint server for biology (2023)

and is associated with poor patient prognosis. STIM2 downregulation induces PERK/ATF4 dependent ER stress in colorectal cancer.Increased ER stress drives colorectal cancer metabolic reprogramming, growth, and metastasis.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
case report
cell proliferation
transcription factor
oxidative stress