Integrative histopathological and immunophenotypical characterisation of the inflammatory microenvironment in spitzoid melanocytic neoplasms.
Lisa M HillenHendrik L D VandyckDaphne J G LeunissenBianca T A de GreefFrancesca M BosisioAxel Zur HausenJoost van den OordVéronique WinnepenninckxPublished in: Histopathology (2020)
Our findings demonstrate that Spitz tumours are highly immunogenic lesions. Inflammation with the presence of lymphocytic aggregates predominated in SN, but was not distinctive for this melanocytic category. A strong and intense inflammation was suggestive of an underlying malignancy. The infiltrating cytotoxic T lymphocyte subsets in Spitz tumours deserve further investigation in larger study cohorts to elucidate prognostic and immuno-oncological therapeutic relevance.