Genetic landscape of early-onset dementia in Hungary.

Dora CsabanAnett IllesToth-Bencsik RenataPeter BaliczaKlara PentelenyiViktor MolnarAndras GezsiZoltan GroszAniko GalTibor KovacsPeter KlivenyiMária Judit Molnár

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2022)

Based on our observations, a comprehensive, targeted panel of next-generation sequencing (NGS) testing investigating several neurodegeneration-associated genes may accelerate the path to achieve the proper genetic diagnosis since phenotypes are present on a spectrum. This can also reveal hidden correlations and overlaps in neurodegenerative diseases that would remain concealed in separated genetic testing.

Keyphrases

early onset
genome wide
copy number
late onset
dna methylation
single cell
mild cognitive impairment
cognitive impairment
cancer therapy
drug delivery
circulating tumor
transcription factor