KLK3 germline mutation I179T complements DNA repair genes for predicting prostate cancer progression.
Jianfeng XuZhuqing ShiJun WeiRong NaW Kyle ResurreccionChi-Hsiung WangChris SampleMisop HanS Lilly ZhengKathleen A CooneyBrian T HelfandWilliam B IsaacsPublished in: Prostate cancer and prostatic diseases (2022)
Two different cohorts consistently demonstrate that KLK3 I179T and RPMs of nine commonly tested DNA repair genes are complementary for predicting PCa progression. These results are highly relevant to PCa germline testing and provide critical information for KLK3 I179T to be considered in guidelines.