Login / Signup

Circulating Concentrations of C-Type Natriuretic Peptides Increase with Sacubitril/Valsartan Treatment in Healthy Young Men.

Simon ThonsgaardTimothy C R PrickettLasse H HansenNicolai J Wewer AlbrechtsenUlrik Ø AndersenDijana TerzicPeter PlomgaardFinn GustafssonJens P GoetzePeter D Mark
Published in: Clinical chemistry (2022)
Sacubitril/valsartan augments circulating concentrations of both bioactive CNP and NT-proCNP in healthy young men. The increase in bioactive CNP is most likely caused by de novo synthesis and secretion rather than diminished breakdown through neprilysin inhibition.ClinicalTrials.gov registration number NCT03717688.
Keyphrases
  • middle aged
  • ejection fraction
  • amino acid
  • tissue engineering