Network analyses reveal negative link between changes in adipose tissue GDF15 and BMI during dietary induced weight loss.
Alyssa ImbertNathalie VialaneixJulien MarquisJulie Vion-ChambrialAline CharpagneSylviane MetaironClaire LaurensCedric MoroNathalie BouletOndine WalterGrégory LefebvreJörg HagerDominique LanginWim H M SarisArnie AstrupNathalie ViguerieArmand ValsesiaPublished in: The Journal of clinical endocrinology and metabolism (2021)
Network analyses identified a novel AT feature with GDF15 upregulated with calorie restriction induced weight loss, concomitantly to macrophage markers. In AT, GDF15 was expressed in preadipocytes and macrophages where it was a hallmark of anti-inflammatory cells.
Keyphrases
- weight loss
- adipose tissue
- bariatric surgery
- high glucose
- roux en y gastric bypass
- diabetic rats
- anti inflammatory
- induced apoptosis
- gastric bypass
- machine learning
- body mass index
- weight gain
- high fat diet
- endothelial cells
- metabolic syndrome
- dna methylation
- single cell
- skeletal muscle
- cell proliferation
- network analysis
- glycemic control
- stress induced