Development of a Novel Rat Knee Osteoarthritis Model Induced by Medial Meniscus Extrusion.
Daisuke FukuiDaisuke NishiyamaManabu YamanakaHidenobu TamaiNaoko NishioMamoru KawakamiHiroshi YamadaPublished in: Cartilage (2023)
The newly developed MME model reproduced the characteristic pathology of MME in clinical practice, such as severe pain, inflammation, and rapid progression of osteoarthritis. The MME model, which might more closely mimic human knee osteoarthritis (OA), could be a useful model for elucidating the pathophysiology and considering therapeutic management for knee OA.