Pathogenic Potential of Eomesodermin-Expressing T-Helper Cells in Neurodegenerative Diseases.
Tomomi KanazawaWakiro SatoBen J E RaveneyDaiki TakewakiAtsuko KimuraHiromi YamaguchiYuma YokoiReiko SaikaYuji TakahashiTsuneo FujitaShinji SaikiAkira TamaokaShinji OkiTakashi YamamuraPublished in: Annals of neurology (2024)
Eomesodermin-expressing (Eomes + ) T-helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. We found that Eomes + Th cell frequency was increased in the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme B production by Th cells from such patients was high compared with controls. A high frequency of Eomes + Th cells was observed in the initial (acutely progressive) stage of amyotrophic lateral sclerosis, and a positive correlation between Eomes + Th cell frequency and cognitive decline was observed in Alzheimer's disease patients. Therefore, Eomes + Th cells may be involved in the pathology of amyotrophic lateral sclerosis and Alzheimer's disease. ANN NEUROL 2024;95:1093-1098.
Keyphrases
- amyotrophic lateral sclerosis
- cognitive decline
- multiple sclerosis
- induced apoptosis
- end stage renal disease
- high frequency
- newly diagnosed
- ejection fraction
- cell cycle arrest
- mild cognitive impairment
- cell death
- signaling pathway
- regulatory t cells
- cell proliferation
- patient reported outcomes
- bone marrow
- white matter
- pi k akt
- neural network