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Advanced Magnetic Resonance Imaging (MRI) to Define the Microvascular Injury Driven by Neuroinflammation in the Brain of a Mouse Model of Hypertension.

Lorenzo CarnevaleMarialuisa PerrottaFrancesco MastroiacovoSara PerrottaAgnese MigliaccioValentina FardellaJacopo PacellaStefania FardellaFabio PallanteRaimondo CarnevaleDaniela CarnevaleGiuseppe Lembo
Published in: Hypertension (Dallas, Tex. : 1979) (2024)
Overall, we have used translational tools to comprehensively characterize brain injury in a mouse model of hypertension induced by chronic pressure overload. We have identified early cerebrovascular damage in hypertensive mice, sustained by CD8+IFN-γ+T lymphocytes, which fuel neuroinflammation to establish the injury of brain capillaries.
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