Risk of neural tube defects according to maternal body mass index: a systematic review and meta-analysis.

Flaminia Vena Valentina D'AmbrosioVanessa PaladiniEnrica SaluzziDaniele Di MascioChiara BoccheriniLorenzo SpinielloAlessandro MondoAntonio PizzutiAntonella Giancotti

Published in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2021)

Obese pregnant women are at significantly higher risk NTDs, while no significant difference has been found in overweight and underweight pregnant women. Key message Obese pregnant women are at significantly higher risk of NTDs, such as spina bifida compared with normal weight women. No difference was found when comparing overweight and underweight with normal weight women.

Keyphrases

pregnant women
weight loss
pregnancy outcomes
body mass index
weight gain
bariatric surgery
physical activity
birth weight
polycystic ovary syndrome
adipose tissue
metabolic syndrome
type diabetes
obese patients
insulin resistance
body weight