Tenofovir Douche as HIV Pre-Exposure Prophylaxis for Receptive Anal Intercourse: Safety, Acceptability, Pharmacokinetics, & Pharmacodynamics (DREAM 01).

Ethel D WeldIan McGowanPeter AntonEdward J FuchsKen HoAlex Carballo-DieguezLisa C RohanRebecca GiguereRhonda BrandStacey EdickRahul P BakshiTeresa ParsonsMadhuri ManoharAaron SeigelJared EngstromJulie ElliottCindy JacobsonChristina BagiaLin WangAmer Al-KhoujaDouglas J HartmanNamandje N BumpusHans M L SpiegelMark A MarzinkeCraig W Hendrix

Published in: The Journal of infectious diseases (2023)

All three tenofovir douches achieved tissue tenofovir-diphosphate concentrations and colorectal antiviral effect exceeding oral TDF with lower systemic tenofovir. tenofovir douches may provide a single dose, on-demand, behaviorally-congruent PrEP option and warrant continued development.

Keyphrases

antiretroviral therapy
hiv infected
hiv positive
human immunodeficiency virus
men who have sex with men
hiv aids
hepatitis c virus
high grade
south africa
drug induced