Aging-Related Mitochondrial Dysfunction is Associated with Fibrosis in Benign Prostatic Hyperplasia.

Alexis E Adrian Teresa T LiuLaura E PascalScott R BauerDonald B DeFrancoWilliam A Ricke

Published in: The journals of gerontology. Series A, Biological sciences and medical sciences (2023)

Complex I dysfunction is a potential contributor to fibrosis and lower urinary tract dysfunction in aged mice. Oleic acid partially bypasses complex I inhibition and therefore should be further investigated as a mitochondrial modulator for treatment of LUTS/BPH. Hypotheses generated in this investigation offer a heretofore unexplored cellular target of interest for the management of LUTS/BPH.

Keyphrases

benign prostatic hyperplasia
lower urinary tract symptoms
urinary tract
oxidative stress
liver fibrosis
skeletal muscle
replacement therapy
metabolic syndrome
drug induced