Portosystemic shunting prevents hepatocellular carcinoma in non-alcoholic fatty liver disease mouse models.

Andrea PelosoStéphanie LacotteQuentin GexFlorence SlitsBeat MoeckliGraziano OldaniMatthieu TihyAurélie HautefortBrenda KwakLaura Rubbia-BrandtChristian Toso

Published in: PloS one (2023)

The present data show that portosystemic shunting prevents NAFLD-associated HCC, utilizing two independent mouse models. This effect is supported by the development of less steatosis, and a restored liver oxygen level. Portal pressure modulation and shunting deserve further exploration as potential prevention/treatment options for NAFLD and HCC.

Keyphrases

mouse model
insulin resistance
electronic health record
high fat diet
big data
type diabetes
human health
metabolic syndrome
data analysis
deep learning