Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK.
Annmarie RamkissoonKatherine E ChaneyDavid MilewskiRory L WilliamsKwangmin ChoiAdam MillerTanya V KalinJoseph G PresseySara SzaboMohammad AzamDavid A LargaespadaNancy RatnerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Targeting DUSP1 and DUSP6 genetically or with BCI effectively inhibits MPNST cell growth and promotes cell death, in vitro and in xenograft models. The data support further investigation of DUSP inhibition in MPNSTs.