Association of TERT and DSP variants with microscopic polyangiitis and myeloperoxidase-ANCA positive vasculitis in a Japanese population: a genetic association study.

Aya KawasakiNatsumi NambaKen-Ei SadaFumio HiranoShigeto KobayashiKenji NagasakaTakahiko SugiharaNobuyuki OnoTakashi FujimotoMakio KusaoiNaoto TamuraKunihiro YamagataTakayuki SumidaHiroshi HashimotoShoichi OzakiHirofumi MakinoYoshihiro ArimuraMasayoshi HarigaiNaoyuki Tsuchiya

Published in: Arthritis research & therapy (2020)

Unexpectedly, TERT and DSP IPF risk alleles were found to be associated with MPA and MPO-AAV, regardless of the presence of ILD. These findings suggest that TERT and DSP may be novel susceptibility genes to MPA/MPO-AAV and also that some susceptibility genes may be shared between IPF and MPA/MPO-AAV.

Keyphrases

genome wide
gene therapy
idiopathic pulmonary fibrosis
copy number
interstitial lung disease
genome wide identification