Genomic and Single-Cell Landscape Reveals Novel Drivers and Therapeutic Vulnerabilities of Transformed Cutaneous T-cell Lymphoma.

Xiaofei SongShiun ChangLucia Seminario-VidalAlvaro de Mingo PulidoLeticia TordesillasXingzhi SongRhianna A ReedAndrea HarkinsShannen WhiddonJonathan V Nguyen Carlos Moran SeguraChaomei ZhangSean YoderZena SayeghYun ZhaoJane L MessinaCarly M HarroXiaohui ZhangJosé R Conejo-Garcia Anders E BerglundLubomir SokolJianhua ZhangPaulo C Rodriguez James J MuleAndrew P FutrealKenneth Y Tsai Pei-Ling Chen

Published in: Cancer discovery (2022)

Our study contributes a key resource to the community with the largest collection of tCTCL biopsies that are difficult to obtain. The multiomics data herein provide the first comprehensive compendium of genomic alterations in tCTCL and identify potential prognostic signatures and novel therapeutic targets for an incurable T-cell lymphoma. This article is highlighted in the In This Issue feature, p. 1171.

Keyphrases

single cell
copy number
rna seq
healthcare
mental health
genome wide
electronic health record
big data
gene expression
human health
risk assessment
climate change