Hepatocellular carcinoma (HCC) is a major cause of death in many countries including Korea. To provide useful and sensible advice for clinical management of patients with HCC, the Korean Liver Cancer Association and National Cancer Center (KLCA-NCC) Korea Practice Guideline Revision Committee has recently revised practice guidelines for the management of HCC. However, there are some differences between practice guidelines and real-life clinical practice for several reasons. In this review, we will describe some key recommendations of the 2022 version of practice guidelines and real-life clinical situation in Korea together with a discussion about efforts needed to reduce the gap between practice guidelines and real-life clinical practice.