Stem cell factor and cKIT modulate endothelial glycolysis in hypoxia.
Hayoung JeongRyul-I KimHyunwoo KooYang Hee ChoiMinju KimHyejin RohSang Gyu ParkJong-Hyuk SungKoung Li KimWonhee SuhPublished in: Cardiovascular research (2024)
We demonstrated that SCF and cKIT signalling regulate angiogenesis by controlling endothelial glycolysis in hypoxia and elucidated the SCF/cKIT/HIF-1α axis as a novel metabolic regulation pathway during hypoxia-driven pathological angiogenesis.