Inhibiting Kiss1 Neurons with Kappa Opioid Receptor Agonists to Treat Polycystic Ovary Syndrome and Vasomotor Symptoms.
Elizabeth A McCarthyDaniel DischinoCaroline MaguireSilvia LeonRajae TalbiEugene CheungClaudio D SchteingartPierre J M RivièreSusan D ReedRobert A SteinerVíctor M NavarroPublished in: The Journal of clinical endocrinology and metabolism (2021)
The inhibition of Kiss1 neuronal activity by activation of kappa receptors shows promise as a novel therapeutic approach to treat both VMS and PCOS in humans.
Keyphrases
- polycystic ovary syndrome
- nuclear factor
- insulin resistance
- toll like receptor
- chronic pain
- pain management
- spinal cord
- signaling pathway
- big data
- sleep quality
- adipose tissue
- cerebral ischemia
- metabolic syndrome
- spinal cord injury
- skeletal muscle
- inflammatory response
- depressive symptoms
- artificial intelligence
- physical activity