Combination of pioglitazone and dendritic cell to optimize efficacy of immune cell therapy in CT26 tumor models.

Samaneh Tokhanbigli Helia AlavifardHamid Asadzadeh AghdaeiMohammad Reza ZaliKaveh Baghaei

Published in: BioImpacts : BI (2022)

Pioglitazone could efficiently ameliorate the immunosuppressive feature of the tumor microenvironment, mainly through IL-6. Accordingly, applying this drug combined with LPMDCs provoked substantial CD8 positive responses in tumor-challenged animal models.

Keyphrases

cell therapy
dendritic cells
stem cells
machine learning
computed tomography
mesenchymal stem cells
deep learning
magnetic resonance imaging
emergency department
image quality
positron emission tomography
adverse drug
nk cells
pet ct