Denosumab versus bisphosphonates in patients with advanced cancers-related bone metastasis: systematic review and meta-analysis of randomized controlled trials.

Amr MenshawyOmar MattarAli AbdulkarimShiref KasemNoha NasreldinEsraa MenshawySalahuddean MohammedMohamed Abdel-MaboudMohamed GadelkarimGehad Gamal El AshalAhmed Saber Elgebaly

Published in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2018)

Denosumab showed a favorable significant impact on delaying the time to first skeletal-related event and reducing the incidence of radiation to the bone event in comparison to bisphosphonates, with similar efficacy regarding overall survival and time to disease progression. Further large-scale and long-term studies are needed to clarify the long-term efficacy and safety of both regimens.

Keyphrases

bone mineral density
systematic review
postmenopausal women
body composition
meta analyses
soft tissue
bone loss
bone regeneration