A causal variant rs3769823 in 2q33.1 involved in apoptosis pathway leading to a decreased risk of non-small cell lung cancer.

Xu ZhangNa QinJingyi FanChang ZhangQi SunYayun GuMeng ZhuErbao ZhangJuncheng DaiGuangfu JinHongxia MaZhibin HuHongbing Shen

Published in: Cancer biology & medicine (2022)

These results suggested that rs3769823 is the causal variant in chromosome 2q33.1 and is involved in an apoptosis pathway, leading to a decreased risk of NSCLC.

Keyphrases

oxidative stress
cell cycle arrest
endoplasmic reticulum stress
cell death
small cell lung cancer
gene expression
pi k akt
copy number
dna methylation
cell proliferation
brain metastases