Kcnk3 dysfunction exaggerates the development of pulmonary hypertension induced by left ventricular pressure overload.

Mélanie Lambert Pedro Mendes-Ferreira Maria-Rosa GhignaHélène LeRibeuzRui AdãoAngèle BoetVéronique CapuanoCatherine Rucker-MartinCarmen Brás-SilvaRozenn QuarckValérie DomergueJean-Luc VachiéryMarc Humbert Frédéric Perros I David Montani Fabrice Antigny

Published in: Cardiovascular research (2022)

Our results indicate that Kcnk3-LOF is a key event in the pathobiology of PH due to AAC, suggesting that Kcnk3 channel dysfunction could play a potential key role in the development of PH due to LHD.

Keyphrases

pulmonary hypertension
left ventricular
oxidative stress
acute myocardial infarction
pulmonary arterial hypertension
mitral valve
pulmonary artery
coronary artery
climate change
aortic stenosis
human health
transcatheter aortic valve replacement
atrial fibrillation