Targeting Fn14 as a therapeutic target for cachexia reprograms the glycolytic pathway in tumour and brain in mice.
Ingrid Julienne Georgette BurvenichLaura Danielle OsellameAngela RigopoulosNhi HuynhZhipeng CaoNicholas Johannes HoogenraadAndrew Mark ScottPublished in: European journal of nuclear medicine and molecular imaging (2024)
Our results demonstrate that Fn14 receptor activation is linked to glucose metabolism of cachexia-inducing tumours.