Attenuation of neuronal ferroptosis in intracerebral hemorrhage by inhibiting HDAC1/2: Microglial heterogenization via the Nrf2/HO1 pathway.

Zhiwen JiangHeng YangWei NiXinjie GaoXu PeiHanqiang JiangJiabin SuRuiyuan WengYuchao FeiYan-Qin GaoYuxiang Gu

Published in: CNS neuroscience & therapeutics (2024)

Inhibition of HDAC1/2 reduces neuro-ferroptosis by modifying the heterogeneity of microglia via the Nrf2/HO1 pathway, with a particular focus on acetyl-Nrf2. Additionally, this inhibition aids in the faster removal of hematomas and lessens prolonged neurological impairments, indicating novel approach for treating ICH.

Keyphrases

oxidative stress
cell death
inflammatory response
histone deacetylase
signaling pathway
brain injury
pi k akt
single cell
cerebral ischemia
lipopolysaccharide induced
subarachnoid hemorrhage
blood brain barrier