Mesenchymal stromal cells from a progressive pseudorheumatoid dysplasia patient show altered osteogenic differentiation.
Lia PulsatelliCristina ManferdiniElena GabusiErminia MarianiFrancesco UrsiniJacopo CiaffiRiccardo MeliconiGina LisignoliPublished in: European journal of medical research (2022)
Since all regenerative processes require stem cell reservoirs, compromised functionality of MSCs may lead to an imbalance in bone homeostasis, suggesting a potential role of MSCs in the pathological mechanisms of PPRD caused by WNT1-inducible signaling pathway protein-3 (WISP3) mutations. In consideration of the lack of compounds with proven efficacy in such a rare disease, these data might contribute to better identify new specific and effective therapeutic approaches.
Keyphrases
- mesenchymal stem cells
- stem cells
- bone marrow
- umbilical cord
- signaling pathway
- cell therapy
- multiple sclerosis
- bone mineral density
- pi k akt
- electronic health record
- case report
- epithelial mesenchymal transition
- cell proliferation
- protein protein
- big data
- soft tissue
- human health
- bone loss
- induced apoptosis
- postmenopausal women
- bone regeneration
- climate change
- machine learning
- data analysis
- body composition