Detection of changes in synaptic density in amyotrophic lateral sclerosis patients using <sup>18</sup> F-SynVesT-1 positron emission tomography.
Yongxiang TangPan LiuWanzhen LiZhen LiuMing ZhouJian LiYanchun YuanLiangjuan FangMengli WangLu ShenYiyun HuangBeisha TangJun-Ling WangShuo HuPublished in: European journal of neurology (2022)
This approach may provide a direct measure of synaptic density, and it therefore might represent a potentially useful biomarker for ALS diagnosis, as well as for estimating the cognitive decline and site of onset in ALS. <sup>18</sup> F-SynVesT-1-PET is presently not justified as a routine investigation to detect evidence of brain dysfunction leading to progression in ALS.
Keyphrases
- positron emission tomography
- cognitive decline
- computed tomography
- amyotrophic lateral sclerosis
- mild cognitive impairment
- pet ct
- pet imaging
- end stage renal disease
- ejection fraction
- newly diagnosed
- oxidative stress
- white matter
- patient reported outcomes
- multiple sclerosis
- blood brain barrier
- subarachnoid hemorrhage