A comprehensive review of m 6 A research in cervical cancer.
Jing HuShizhi WangXiuting LiPublished in: Epigenomics (2024)
Cervical cancer (CC) remains one of the most common malignancies among women worldwide, posing a serious threat to women's health. N6-methyladenosine (m 6 A) modification, as the most abundant type of RNA methylation modification, and has been found to play a crucial role in various cancers. Current research suggests a close association between RNA m 6 A modification and the occurrence and progression of CC, encompassing disruptions in m 6 A levels and its regulatory machinery. This review summarizes the current status of m 6 A modification research in CC, explores the mechanisms underlying m 6 A levels and regulators (methyltransferases, demethylases, reader proteins) in CC and examines the application of small-molecule inhibitors of m 6 A regulators in disease treatment. The findings provide new insights into the future treatment of CC.
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