New approaches to ondansetron and alosetron inspire a versatile, flow photochemical method for indole synthesis.
Wei SunWilliam A T RaimbachLuke D ElliottKevin I Booker-MilburnDavid C HarrowvenPublished in: Chemical communications (Cambridge, England) (2021)
An oxidative photocyclisation of N-arylenaminones to indoles is described, that mirrors the Fischer indole synthesis but uses anilines in place of arylhydrazines. Its value is exemplified with new approaches to the WHO-listed APIs ondansetron and alosetron.
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