Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy.
Daniel GordinHetal S ShahTakanori ShinjoRonald St-LouisWeier QiKyoungmin ParkSamantha M PaniaguaDavid M PoberI-Hsien WuVanessa BahnamMegan J BrissettLiane J TinsleyJonathan M DreyfussHui PanYutong DongMonika A NiewczasPeter AmentaThorsten SadowskiAimo KanntHillary A KeenanGeorge Liang KingPublished in: Diabetes care (2019)
Elevation of enzymes involved in the metabolism of intracellular free glucose and its metabolites in renal glomeruli is connected to preserving kidney function in both type 1 and type 2 diabetes. The renal profile of elevated glycolytic enzymes and reduced toxic glucose metabolites is reflected in the circulation, supporting their use as biomarkers for endogenous renal protective factors in people with diabetes.